When you lose someone, you don't have to just lose them to death. There are many other ways to lose them. You can lose them to greed, to a group, to drugs, to alcohol or even to someone else.
When someone is lost to these things, they can lose their own personality. Like in the case of drugs or alcohol. Their brain is not what it was, their personality diminishes until they are no longer who they were. These processes generally don't happen quickly, someone slowly loses their own personality or changes their own to change who they once were. That's when you "lose" them.
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